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What is Garcinia Cambogia?

Garcinia Cambogia is a plant that looks like a small, green pumpkin and is used in many traditional Asian dishes for its sour flavor.

In the skin of the fruit, there is a large amount of a natural substance called Hydroxycitric Acid (HCA). This is the active ingredient in Garcinia Cambogia extract and the substance that produces the weight loss effects.

Last year, Dr. Oz featured Garcinia Cambogia on his show and seemed very excited about it… he even used the word magic and said that it might be “the most exciting breakthrough in natural weight loss to date”.

The proposed mechanism of action is via the inhibition of a fat producing enzyme called Citrate Lyase, making it more difficult for the body to produce fat out of carbohydrates. Several studies in rats showed that Garcinia Cambogia consistently leads to significant weight loss. Furthermore, animal studies showed increased levels of the neurotransmitter serotonin. This could theoretically lead to reduced appetite and cravings.

A review published in the Journal of Obesity found that people who took Garcinia Cambogia lost more than people who didn't take it, over a period of 12 weeks (Marquez et al, 2012), which is the longest clinical study to date.

Adverse Reactions and Safety

A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea (Pittler et al., 2005, Soni et al, 2004).

Marquez and his coworkers (2012) state that “at the doses usually administered, no differences have been reported in terms of side effects or adverse events (those studied) in humans between individuals treated with G. cambogia and controls.” More recently, Clouatre & Preuss, 2013, also reported Garcinia Cambogia to be a completely safe supplement.

Slender Wonder’s Garcinia Cambogia Plus is furthermore enriched with added Apple Pectin, 5-hydroxy Tryptophan and Chromium Polynicotinate.

Apple pectin is a soluble fiber and after it enters your stomach, it forms a gelatinous mass that may support weight loss by creating a feeling of fullness.

When the brain is flooded with serotonin, satiety normally occurs. A serotonin deficiency has been associated with the carbohydrate binging. Obese individuals have low blood tryptophan levels, which indicate that their overeating patterns may be related to a serotonin deficiency in the brain. Tryptophan is needed to produce serotonin in the brain. When obese patients were given Tryptophan before meals, a significant decrease in caloric consumption was observed.

Chromium is important for insulin function, and too little chromium means that hormone production is not functioning at optimum level. An imbalance in insulin (the hormone the body uses to regulate sugar) can lead to higher risk for weight gain, cholesterol, and fat. Using chromium may help to stabilise blood sugar and insulin levels, and helps the body to use the sugar for energy like it is meant to.

Take 2 x Garcinia Cambogia Plus, twice per day, two hours before a meal to suppress the appetite and help to block the fat production.

References:

Clouatre DL & Preuss HG (2013). Hydroxycitric acid does not promote inflammation or liver toxicity. World J Gastoenterol. 19(44):8160-2;
Marquez F et al (2012). Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci Nutr, 52(7):585-94)
Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.
Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.
Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi D. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol . 2004;42(9):1513-1529.
Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.
Cavaliere H, Medeiros-Neto G. The anorectic effect of increasing doses of L-tryptophan in obese patients. Eat Weight Disord. 1997 Dec;2(4):211-5

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